Clone RM192: Specific detection of Histone-H3-K27M
Clone RM192 by RevMAb Biosciences allows the specific detection of the Histone H3 K27M mutant in FFPE-tissue samples. The lysin residue (K) at position 27 of the amino acid chain is replaced by a methionine residue (M) in K27M mutant proteins. The monoclonal rabbit antibody does not cross react with wild-type Histone H3.
Western Blot analysis of cell lysates prepared from 293T transfected with a DNA construct encoding wild type (WT) or K27M mutant proteins of Histone H3.3, using anti-Histone H3 K27M rabbit monoclonal antibody, clone RM192.
Image courtesy of Sebastian Brandner MD, Division of Neuropathology and Dept. of Neurodegenerative Disease, UCL Institute of Neurology, London, UK