IREM-2 (CD300e) Clone UP-H2 – Marker for myeloid cells

  • recommended in the EuroFlow panel for AML/MDS
  • complete recognition of all monocytic cells (monoblasts, promonocytes, monocytes, dendritic cells) to prevent loss of crucial information otherwise inherent to other markers
  • classification of the different types of myeloid leukemias, especially acute monoblastic and monocytic leukemias (FAB subtypes M5a and M5b) – discrimination between acute myeloid leukemia Monocytic, Monoblastic and Chronic myelomonocytic leukemia
  • high stain index


With HLA-DR clone L243 for the violet laser

More conjugates of IREM-2 clone UP-H2


IREM-2 > J Immunol. 2004 Dec 1;173(11):6703-11: Molecular characterization of a novel immune receptor restricted to the monocytic lineage. Aguilar H, Alvarez-Errico D, García-Montero AC, Orfao A, Sayós J, López-Botet M.

IREM-2 (UP-H2) APC > Leukemia. 2012 Sep;26(9):1908-75: EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes. J J M van Dongen et al.

IREM-2 (UP-H2) PE > Cytometry B Clin Cytom. 2016 Jan;90(1):91-100: Utility of CD54, CD229, and CD319 for the identification of plasma cells in patients with clonal plasma cell diseases. Pojero F, Flores-Montero J, Sanoja L, Pérez JJ, Puig N, Paiva B, Bottcher S, van Dongen JJ, Orfao A; EuroFlow group.