Anti-H3.3G34R Mutant (Hu) from Rabbit (RM240) – unconj.
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Overview
SKU 31-1120-00-L Specificity Species Reactivity Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application Conjugation Format in PBS without Mg2+ and Ca2+ (pH 7.4), ProteinA/G purified antibody (from culture supernatant)
Application Note No cross reactivity with wild type Histone H3.3., Reacts to the Histone H3.3 G34R mutant
Product line / Topic Intended Use Temperature - Storage Search Code Manufacturer / Brand - Datasheets and Downloads
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Additional Product Information
This antibody reacts to the Histone H3.3 G34R mutant. No cross reactivity with wild type Histone H3.3
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Images
Western Blot analysis of cell lysates prepared from 293T, transfected with a DNA construct encoding G34R mutant or wild type proteins of Histone H3.3, using anti-Histone H3.3 G34R clone RM240. IHC of clinically validated FFPE Glioblastoma tumor tissues with H3.3 G34R expression, using anti-histone H3.3 G34R rabbit monoclonal antibody, Clone RM240. Clinically validated to be Positive for H3.3 G34R Mutation. Image courtesy of Dr. Sebastian Brandn IHC of clinically validated FFPE Glioblastoma tumor tissues, using anti-histone H3.3 G34R rabbit monoclonal antibody, Clone RM240. Clinically validated to be Negative for H3.3 G34R Mutation. Image courtesy of Dr. Sebastian Brandner, UCL Institute of Neuro ICC staining of primary human cell lines expressing WT and H3.3 G34R Mutation. Image courtesy of Dr. Nada Jabado, McGill University, Montreal, Quebec, Canada.
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