Anti-CD23 (Hu,Mo) from Mouse (MHM6) – unconj.

In lymphoid tissue, the antibody labels a variable proportion of mantle zone lymphocytesand a fraction of dendritic reticulum cells. In lymph nodes with progressive germinal centretransformation, the number and staining intensity of small follicular lymphocytes areincreased. Essentially no staining is seen on splenic marginal zone lymphocytes.The CD23 antigen is expressed on neaoplatic cells from cases of B-Cell chroniclymphocytic leukemia and some cases of centroblastic/centrocytic lymphoma, but not inother types of lymphoid neoplasms.A large number of normal non-lymphoid human tissues do not react with CD23, (CloneMHM6) including: central nervous system, endocrine glands, gastrointestinal, respiratory,urinary, reproductive system, skin, bone, cartilege, connective tissue, muscle, peripheralnerves, vessels, mesothelium, synovium, placente and umbelical cord.