Anti-NGFR (TNFRSF16) (Hu) from Mouse (IHC637) – unconj.
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Overview
SKU AB-138366 Specificity Species Reactivity Immunogen Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections)
Conjugation Dilution Format < 0.1% NaN3, 1% BSA, concentrate, in Tris buffer (pH 7.3-7.7), ProteinA/G purified antibody
Intended Use Temperature - Storage Temperature - Transport Manufacturer / Brand Uniprot_ID Gene_ID Alias CD271, Gp80-LNGFR, LNGFR, Low Affinity Nerve Growth Factor Receptor, Low affinity neurotrophin receptor p75NTR, NGFR, p75 neurotrophin Receptor, P75(NTR), TNFRSF16, Tumor necrosis factor receptor superfamily member 16
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Additional Product Information
Nerve Growth Factor Receptor (NGFR), also known as p75, P-75NTR, or CD271, is a neurotrophin receptor belonging to the tumour necrosis factor receptor family. It is expressed mainly in Schwann cells and neurons, as well as a number of other non-neuronal cell types, and is also expressed in melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurofibromas, neurotized nevi (type C melanocytes), and other neural crest cell or tumour derivatives. It has been suggested that NGFR may act as a tumour suppressor indicated in prostate and urothelial cancer, and Anti-NGFR is often used in adjunct with S100, to aid in the diagnosis of desmoplastic and neurotrophic malignant melanomas. Anti-NGFR is also useful as an aid in the diagnosis of breast malignancy, as the antibody labels the myoepithelial cells of breast ducts and intralobular fibroblasts of breast ducts.
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Images
Immunohistochemical staining of formalin-fixed and paraffin-embedded (FFPE) human cervix tissue section using anti-Nerve Growth Factor Receptor (NGFR) mouse monoclonal antibody (Clone IHC637).
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