Anti-Phospho-NTRK1 (Tyr680+Tyr681) (Hu,Ms,Rt) from Rabbit (pAb) – unconj.
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Overview
SKU AF3072-02 Specificity Species Reactivity Immunogen Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application ELISA, Immunohistochemistry (frozen sections), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections), Western Blot
Conjugation Dilution Immunohistochemistry (IHC): 1:50 – 1:500, Western Blot (WB): 1:500 – 1:2,000
Format 0,02% NaN3, 150 mM NaCl, 1mg/ml Antibody, 50% Glycerol, affinity purified antibody (from antiserum), in PBS without Mg2+ and Ca2+ (pH 7.4), purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns
Intended Use Temperature - Storage Temperature - Transport Manufacturer / Brand Uniprot_ID Alias High affinity nerve Growth Factor Receptor, Neurotrophic Tyrosine Kinase, Receptor Type 1, NTRK1, Phospho-NTRK1 (Tyr680+Tyr681), TrkA
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Additional Product Information
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.
Phospho-Trk A (Tyr680+Tyr681) Antibody detects endogenous levels of Trk A only when phosphorylated at Tyrosine 680+Tyrosine 681
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