Anti-Phospho-MOB1A (Ser9) (Hu,Ms,Rt) from Rabbit (pAb) – unconj.
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Overview
SKU AF7414-02 Specificity Species Reactivity Immunogen Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application ELISA, Immunohistochemistry (frozen sections), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections), Western Blot
Conjugation Dilution Immunohistochemistry (IHC): 1:50 – 1:200, Western Blot (WB): 1:500 – 1:2,000
Format 0,02% NaN3, 150 mM NaCl, 1mg/ml Antibody, 50% Glycerol, affinity purified antibody (from antiserum), in PBS (pH 7.4)
Intended Use Temperature - Storage Temperature - Transport Manufacturer / Brand Uniprot_ID - Datasheets and Downloads
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Additional Product Information
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Phospho-MOB1A (S9) Antibody detects endogenous levels of MOB1A only when phosphorylated at S9
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