Human VEGF-D (rec. protein)-unconj.

401,00 

10 µg
Compare
SKU: CYT-075848 Category: Tag:
  • Overview
    SKU CYT-075848
    Species

    Protein

    Source

    Application

    Conjugation

    Maximum Absorption

    Maximum Emission

    Format

    Intended Use

    Product line / Topic

    Search Code

    , ,

    Manufacturer / Brand

  • Additional Product Information
    VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymph angiogenesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-D is a 13.1 kDa non-disulfide linked homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.
Contact
Order:
Tel.: +49 (0)89 3799666-6
Consultation
Tel.: +49 (0)89 3799666-6