Mouse HGF (rec. protein)-unconj.

280,00 

20 µg

Estimated delivery time: 6 business days

  • Overview
    SKUCYT-077035
    Species

    Protein

    Source

    Application

    , ,

    Conjugation

    Maximum Absorption

    Maximum Emission

    Format

    Intended Use

    Product line / Topic

    Search Code

    , ,

    Manufacturer / Brand

  • Additional Product Information
    HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Murine HGF is expressed as a linear 728 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (a-chain and b-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The a-chain consists of 463 amino acid residues and four kringle domains. The b-chain consists of 233 amino acid residues.
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