Anti-SREBP1 Ab-1 (Hu,Hm) from Mouse (Clone: 2A4) – unconj. ABF
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SKU DLN-006772 Specificity Ab Species Reactivity Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application Conjugation Format Application Note Positive Control Product line / Topic Intended Use Temperature - Storage Search Code Manufacturer / Brand
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SREBP-1 and 2 are transcription factors which participate in the control of cholesterol homeostasis. SREBPs proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. Upon activation of SREBP-1 or 2, an ~480-500 amino acid, N-terminal cleavage fragment of these proteins enters the nucleus and activates transcription of enzymes and other proteins required for cholesterol synthesis. SCA (SREBP-cleavage activity) and caspase-3 proteases cleave SREBPs. SREBP proteins containing point mutations at caspase-3 cleavage sites (Asp460 in SREBP-1 and Asp468 in SREBP-2) do not become cleaved following induction of apoptosis, suggesting that SREBPs may play some role in apoptotic processes.