Anti-CFTR Ab-4 (Hu,Ms,Rt,Ro) from Mouse (Clone: M3A7) – unconj.
-
Overview
SKU DLN-006996 Specificity Ab Species Reactivity Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application Immunofluorescence, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections), Immunoprecipitation
Conjugation Format Positive Control Product line / Topic Intended Use Temperature - Storage Search Code Manufacturer / Brand - Datasheets and Downloads
-
Additional Product Information
CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3′,5′-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Contact