Anti-vWF (Factor VIII Rel. Antigen) (Hu) from Mouse (IIIE2.34) – unconj.

von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma, and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi is sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers, although not all tumors of endothelial differentiation contain this antigen.