Anti-IDH1 R132H (Hu) aus Maus (H09) – unkonj. – vorverdünnt RTU
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Übersicht
Artikelnummer DIA-H09-L Spezifität Spezies-Reaktivität Immunogen Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung Konjugation Verdünnung vorverdünnt, gebrauchsfertig (erfordert keine weitere Verdünnung)
Format gebrauchsfertig, gereinigter vorverdünnter Antikörper, in Antikörper-Verdünnungspuffer
Anwendungshinweis Produktlinie / Thema Zweckbestimmung Temperatur - Lagerung Temperatur - Transport Suchcode Hersteller / Marke Uniprot_ID Gene_ID Alias Cytosolic NADP-isocitrate dehydrogenase, IDP, Isocitrate dehydrogenase [NADP] (cytoplasmic), Isocitrate Dehydrogenase 1, Soluble, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD
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Weitere Produktinformationen
Antibody clone H09 reacts specifically with the isocitrate dehydrogenase 1 (IDH1) R132H point mutation in tissue sections from formalin-fixed brain tumor.
Heterozygous point mutations of IDH1 codon 132 are frequent in World Health Organization (WHO) grade II and III gliomas. IDH1 R132H mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors. The high frequency and distribution of the IDH1 R132H mutation among specific brain tumor entities allow the highly sensitive and specific discrimination of various tumors by immunohistochemistry, such as anaplastic astrocytoma from primary glioblastoma or diffuse astrocytoma WHO grade II from pilocytic astrocytoma or ependymoma. Noteworthy is the discrimination of the infiltrating edge of tumors with IDH1 mutation from reactive gliosis.
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Bilder
IDH1 R132H: infiltration zone glioma IDH1 R132H: Cortex infiltrated by oligodendroglioma IDH1 R132H: Double staining of GFP and clone H09 IDH1 R132H: Identification of single tumor cells IDH1 R132H: infiltrating glioma cells IDH1 R132H: strong reaction on mutated diffuse astrocytoma IDH1 R132H: tumor center of anaplastic oligoastrocytoma.