Anti-Phospho-TLK1 (Ser743) (Hu,Ms) aus Kaninchen (pAk) – unkonj.
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Übersicht
Artikelnummer AF2425-01 Spezifität Spezies-Reaktivität Immunogen A synthesized peptide derived from human TLK1 around the phosphorylation site of Ser743.
Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung Immunhistochemie (Gefrierschnitte), Immunhistochemie (IHC), Immunhistochemie (Paraffingewebe), Western Blot
Konjugation Verdünnung Immunhistochemie (IHC): 1:50 – 1:200, Western Blot (WB): 1:500 – 1:2.000
Format 0,02% NaN3, 150 mM NaCl, 1mg/ml Antikörper, 50% Glycerol, affinitätsgereinigter Antikörper (aus Antiserum), gereinigt durch sequentielle Chromatographie an Phospho- und Nicht-Phospho-Peptid-Affinitätssäulen, in PBS without Mg2+ and Ca2+ (pH 7,4)
Zweckbestimmung Temperatur - Lagerung Temperatur - Transport Hersteller / Marke Uniprot_ID Alias Phospho-TLK1 (Ser743), PKU-beta, Serine/threonine-protein kinase tousled-like 1, TLK1, Tousled-like kinase 1
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Weitere Produktinformationen
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at ‘Ser-10’.
Phospho-TLK1 (Ser743) Antibody detects endogenous levels of TLK1.
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