Anti-Phospho-TSC2 (Tyr1571) (Hu,Ms,Rt) aus Kaninchen (pAk) – unkonj.
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Übersicht
Artikelnummer AF4438-02 Spezifität Spezies-Reaktivität Immunogen A synthesized peptide derived from human Tuberin/TSC2 around the phosphorylation site of Tyr1571
Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung Konjugation Verdünnung Format 0,02% NaN3, 150 mM NaCl, 1mg/ml Antikörper, 50% Glycerol, affinitätsgereinigter Antikörper (aus Antiserum), gereinigt durch sequentielle Chromatographie an Phospho- und Nicht-Phospho-Peptid-Affinitätssäulen, in PBS without Mg2+ and Ca2+ (pH 7,4)
Zweckbestimmung Temperatur - Lagerung Temperatur - Transport Hersteller / Marke Uniprot_ID Alias Phospho-TSC2 (Tyr1571), TSC2, Tuberin, Tuberous Sclerosis Protein 2
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In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity).
Phospho-Tuberin/TSC2 (Tyr1571) Antibody detects endogenous levels of Tuberin/TSC2 only when phosphorylated at Tyr1571
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