Anti-Phospho-CD31/PECAM-1 (Tyr690) (Hu,Ms,Rt) aus Kaninchen (pAk) – unkonj.
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Übersicht
Artikelnummer AF8016-02 Spezifität Spezies-Reaktivität Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung ELISA (Enzyme Linked Immunosorbent Assay), Immunhistochemie (Gefrierschnitte), Immunhistochemie (IHC), Immunhistochemie (Paraffingewebe), Western Blot
Konjugation Verdünnung Immunhistochemie (IHC): 1:50 – 1:200, Western Blot (WB): 1:1.000 – 1:3.000
Format 0,02% NaN3, 150 mM NaCl, 1mg/ml Antikörper, 50% Glycerol, affinitätsgereinigter Antikörper (aus Antiserum), gereinigt durch sequentielle Chromatographie an Phospho- und Nicht-Phospho-Peptid-Affinitätssäulen, in PBS without Mg2+ and Ca2+ (pH 7,4)
Zweckbestimmung Temperatur - Lagerung Temperatur - Transport Hersteller / Marke Uniprot_ID Alias CD31, EndoCAM, GPIIA', PECA1, Pecam-1, Pecam1, Phospho-CD31/PECAM-1 (Tyr690), Platelet endothelial cell adhesion molecule, Platelet/Endothelial Cell Adhesion Molecule, Platelet/Endothelial Cell Adhesion Molecule 1
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Weitere Produktinformationen
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells, PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity).
PECAM-1 (Phospho-Tyr690) Antibody detects endogenous levels of PECAM-1 only when phosphorylated at Tyr690