Anti-Phospho-EPHA5 (Tyr650) (Hu,Ms,Rt) aus Kaninchen (pAk) – unkonj.

459,00 €
exkl. MwSt. Versandkostenfrei innerhalb Deutschlands
Voraussichtliche Lieferzeit: 15 Werktage
- Übersicht
Artikelnummer AF8426-02 Spezifität Spezies-Reaktivität Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung Konjugation Verdünnung Format 0,02% NaN3, 150 mM NaCl, 1mg/ml Antikörper, 50% Glycerol, affinitätsgereinigter Antikörper (aus Antiserum), gereinigt durch sequentielle Chromatographie an Phospho- und Nicht-Phospho-Peptid-Affinitätssäulen, in PBS without Mg2+ and Ca2+ (pH 7,4)
Immunogen A synthesized peptide derived from human EPHA5 (Phospho-Tyr650)
Zweckbestimmung Temperatur - Lagerung Temperatur - Transport Hersteller / Marke Uniprot_ID Alias - Datenblätter
- Weitere ProduktinformationenReceptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).
EPHA5 (Phospho-Tyr650) Antibody detects endogenous levels of EPHA5 only when phosphorylated at Tyr650