Anti-GRK2 (Hu,Ms,Rt,Mo) aus Maus – unkonj.
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Übersicht
Artikelnummer BF0499-01 Spezifität Spezies-Reaktivität Immunogen Wirtsspezies Isotyp Klonalität (Mono-/Polyklonal) Anwendung ELISA (Enzyme Linked Immunosorbent Assay), Immuncytochemie, Immunfluoreszenz, Immunhistochemie (Gefrierschnitte), Immunhistochemie (IHC), Immunhistochemie (Paraffingewebe), Western Blot
Konjugation Verdünnung ELISA 1:10.000, Immuncytochemie (ICC): 1:200 – 1:1.000, Immunhistochemie (IHC): 1:200 – 1:1.000, Western Blot (WB): 1:500 – 1:2.000
Format 0,02% NaN3, 150 mM NaCl, 1mg/ml Antikörper, 50% Glycerol, affinitätsgereinigter Antikörper, in PBS w/o Ca2+ & Mg2+ (pH 7,4)
Zweckbestimmung Temperatur - Lagerung Temperatur - Transport Hersteller / Marke Uniprot_ID - Datenblätter und Downloads
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Weitere Produktinformationen
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).
GRK2 antibody detects endogenous levels of total GRK2.
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