Anti-TNF-alpha (Hu) aus Kaninchen (Klon: pAk) – unkonj.
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Übersicht
Artikelnummer CYT-026676 Spezifität Spezies-Reaktivität Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung ELISA (Enzyme Linked Immunosorbent Assay), Inhibition/Neutralisation, Western Blot
Konjugation Format Produktlinie / Thema Zweckbestimmung Temperatur - Lagerung Suchcode Hersteller / Marke -
Weitere Produktinformationen
Tumor necrosis factor alpha (TNF-a), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-a is produced by a wide variety of immune and epithelial cell types. Human TNF-a consists of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD). Within the ECD, human TNF-a shares 97% aa sequence identity with rhesus and 71% – 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-a. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form a noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness.
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