Anti-SCF (Ms) aus Kaninchen (Klon: pAk) – unkonj.

257,00 

100 µg

Voraussichtliche Lieferzeit: 6 Werktage

zum Vergleich hinzufügen
Artikelnummer: CYT-075279 Kategorie: Schlagwort:
  • Übersicht
    Artikelnummer CYT-075279
    Spezifität

    Spezies-Reaktivität

    Wirtsspezies

    Isotyp

    Klon

    Klonalität (Mono-/Polyklonal)

    Anwendung

    Konjugation

    Zweckbestimmung

    Suchcode

    , ,

    Hersteller / Marke

  • Weitere Produktinformationen
    Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28-40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Mature mouse SCF consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 36 aa cytoplasmic tail. The ECD shows both N-linked and O-linked glycosylation. Proteolytic cleavage at two alternate sites in the extracellular juxta-membrane region releases a 25 kDa soluble molecule which is comparable to the only form produced by Steel-dickie mutant mice. An alternately spliced isoform of mouse SCF lacks 28 aa that encompasses the primary proteolytic recognition site. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells. Non-covalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/ckit to trigger receptor dimerization and signaling. SCF assists in the recovery of cardiac function following myocardial
Kontakt
Bestellung:
Tel.: +49 (0)89 3799666-6
Beratung:
Tel.: +49 (0)89 3799666-6