Ratte IL-13 (109aa) (rekombinantes Protein)-unkonj.
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Übersicht
Artikelnummer CYT-075650 Spezies Protein Ursprung Anwendung Konjugation Maximale Anregung Maximale Emission Format Zweckbestimmung Produktlinie / Thema Suchcode Hersteller / Marke -
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IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1b, TNF-a, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant rat IL-13 is an 11.9 kDa protein consisting of 109 amino acid residues.
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