Human MIA (Melanoma inhibitory activity) (rekombinantes Protein)-unkonj.
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Übersicht
Artikelnummer CYT-075698 Spezies Protein Ursprung Anwendung Konjugation Maximale Anregung Maximale Emission Format Zweckbestimmung Produktlinie / Thema Suchcode Hersteller / Marke -
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MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family, MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds. .
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