Human VEGF-D (rekombinantes Protein)-unkonj.

401,00 

10 µg

Voraussichtliche Lieferzeit: 6 Werktage

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Artikelnummer: CYT-075848 Kategorie: Schlagwort:
  • Übersicht
    Artikelnummer CYT-075848
    Spezies

    Protein

    Ursprung

    Anwendung

    Konjugation

    Maximale Anregung

    Maximale Emission

    Format

    Zweckbestimmung

    Produktlinie / Thema

    Suchcode

    , ,

    Hersteller / Marke

  • Weitere Produktinformationen
    VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymph angiogenesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-D is a 13.1 kDa non-disulfide linked homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.
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