Anti-DKK2 (Hu) aus Kaninchen – unkonj.
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Übersicht
Artikelnummer CYT-104410 Spezifität Spezies-Reaktivität Wirtsspezies Isotyp Klonalität (Mono-/Polyklonal) Anwendung Konjugation Format Anwendungshinweis Lyophilisat in Wasser (steril) rekonstituieren (Konz. 0,1-1 mg/ml)
Zweckbestimmung Temperatur - Lagerung Hersteller / Marke -
Weitere Produktinformationen
The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 – 4, along with the distantly-related DKK family member DKK-11 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/b-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/b-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/b-catenin signaling cascade. DKK-2 has been shown to both inhibit and enhance canonical Wnt signaling, enhancing Wnt signaling through direct high-affinity binding of DKK-2 to LRP6 during LRP6 overexpression, while inhibiting Wnt signaling and promoting LRP6 internalization through the formation of a ternary complex between DKK-2, LRP6, and Kremen-2. Recombinant Human DKK-2 fused to a C terminal His-tag derived from E. coli has a molecular weight of 26.0 kDa and contains 234 amino acid residues.
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