Anti-PD-L1 (Hu) aus Kaninchen (JAL1) – unkonj.
exkl. MwSt. zzgl. Lieferkosten
Voraussichtliche Lieferzeit: 10 Werktage
Artikelnummer DIA-PDL1-OD Spezifität Spezies-Reaktivität Immunogen Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung
ELISA (Enzyme Linked Immunosorbent Assay), Immunhistochemie (IHC), Immunhistochemie (Paraffingewebe)
Konjugation Verdünnung Format
< 0,1% NaN3, 1% BSA, in Tris Puffer (pH 7,3-7,7), Konzentrat, ProteinA/G-gereinigter Antikörper
Produktlinie / Thema Zweckbestimmung Temperatur - Lagerung Temperatur - Transport Suchcode Hersteller / Marke Uniprot_ID Gene_ID Alias
B7-H, B7H1, CD274, PD-L1, PDCD1-LG1, PDCD1L1, PDCD1LG1, PDL1, Programed Death Ligand 1, Programmed cell death 1 ligand 1, Programmed Cell Death Protein 1 Ligand 1
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Clone JAL1 has been developed specifically for routine immunohistochemical (IHC) detection of PD-L1 in formalin-fixed paraffin-embedded tissue specimen. Moreover, JAL1 has been validated for the identification of PD-L1-positive macrophages and tumor tissues under pathological conditions.
PD-L1, also known as CD274 or B7 homolog 1 (B7-H1) is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on macrophages and activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Moreover, several human cancer cells express PD-L1 at high levels. Binding of PD-L1 with its receptor PD-1 on T cells inhibits t cell proliferation and the production of cytokines, such as interleukin (IL)-2. It has been shown that PD-L1 helps tumor cells to evade anti-tumor immunity and blockade of PD-L1 reduces the growth of tumors in the presence of immune cells.
PD-L1 is commonly over expressed on tumor cells or on non-transformed cells in the tumor microenvironment2. PD-L1 expressed on the tumor cells binds to PD-1 receptors on the activated T cells, which leads to the inhibition of the cytotoxic T cells. These deactivated T cells remain inhibited in the tumor microenvironment.
PD-1 and PD-L1/PD-L2 belong to the family of immune checkpoint proteins that act as co-inhibitory factors, which can halt or limit the development of the T cell response