Anti-MUC1 Ab-5 (Hu,Ms,Ro) aus Hamster, allgemein (Klon: MH1,CT2) – unkonj.
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Übersicht
Artikelnummer DLN-005910 Spezifität Ab Spezies-Reaktivität Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung Durchflusszytometrie (Flow Cytometry), Immunfluoreszenz, Immunhistochemie (IHC), Immunhistochemie (Paraffingewebe), Immunpräzipitation, Western Blot
Konjugation Format Peptid Positivkontrolle Produktlinie / Thema Zweckbestimmung Temperatur - Lagerung Suchcode Hersteller / Marke - Datenblätter und Downloads
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Weitere Produktinformationen
Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost. Muc1 is transcribed as a larger precursor which is cleaved to form a larger mucin like subunit (265-400kDa) and a smaller subunit (14-28kDa) noncovalently associated with each other. Transgenic Muc1 has been shown to associate with all four erbB receptors and localize with erbB1 (EGFR) in lactating glands1. Muc1 can act as a ligand for ICAM-1 on HUVEC cells; it can bind beta-catenin, GSK3beta and it associates with Grb2-SOS upon phosphorylation.
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