Anti-CD8 Ab-1 (Hu) aus Maus (Klon: C8/144B) – unkonj. IHC-RTU

CD8 molecule consists of two chains, termed alpha and Beta chain, which are expressed as a disulphide-alpha beta heterdimer or as an alpha alpha homodimer on T cell subset (cytotoxic/suppressor T cells), thymocytes and NK cells. The majority of CD8+ Tcells expresses CD8 as alphabetaheterodimer. CD8 functions as a coreceptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 alpha chain (but not Beta chain).