Anti-CD137 Ab-1 (Hu) aus Maus (Klon: BBK-2) – unkonj.
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Übersicht
Artikelnummer DLN-010171 Spezifität Ab Spezies-Reaktivität Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung Konjugation Format Produktlinie / Thema Zweckbestimmung Temperatur - Lagerung Suchcode Hersteller / Marke - Datenblätter und Downloads
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Weitere Produktinformationen
4-1BB (also known as CD137) is an inducible receptor-like protein expressed on the cell surface of activated splenic T cells and thymocytes. It exists as both a monomer and a dimer on the surface of activated T cells. 4-1BB is structurally related to the members of NGFR/TNFR superfamily which are characterized by the presence of three-six patterns of a cysteine-rich motif in their extracellular domains. Other members of this family include low affinity NGFR, two receptors for TNF (TNFR-I & TNFR-II), CD30, CD40, OX40, Fas, and CD27. These molecules are involved in cell growth, survival, and death processes. The cytoplasmic domain of 4-1BB include two runs of acidic amino acids, a potential p56^lck^ binding site, five consecutive glycines at the C-terminus, and four potential phosphorylation sites: one tyrosine, two threonine, and one serine.
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