Anti-CD45RA (Hu) aus Maus (135-4C5 (WS IV)) – RPE
exkl. MwSt. zzgl. Lieferkosten
Voraussichtliche Lieferzeit: 10 Werktage
Artikelnummer RA0283-C.5 Spezifität Spezies-Reaktivität Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung Konjugation Maximale Anregung Maximale Emission Format Zweckbestimmung Temperatur - Lagerung Hersteller / Marke
CD45R, also designated as CD45 and PTPRC, has been identified as a transmembrane glycoprotein broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphotyrosine phosphatase. This antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.