Anti-Cyclin D1 (Hu,Rb,Rt,Ms,Sw,Ca,Ck,Mo,Ro) aus Maus (DCS-6) – unkonj.
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Übersicht
Artikelnummer RA0426-C.5 Spezifität Spezies-Reaktivität Affe, Huhn, Human, Kaninchen, Katze, Maus, Nagetiere, Ratte, Schwein
Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung Durchflusszytometrie (Flow Cytometry), Immunhistochemie (Gefrierschnitte), Immunhistochemie (IHC), Immunhistochemie (Paraffingewebe), Immunpräzipitation
Konjugation Format Zweckbestimmung Temperatur - Lagerung Hersteller / Marke -
Weitere Produktinformationen
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11, 14)(q13, q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
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