Anti-MCAM / MUC18 / CD146 (Hu) aus Maus (MUC18/1130) – unkonj.
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Übersicht
Artikelnummer RA0444-C.5 Spezifität Spezies-Reaktivität Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung Durchflusszytometrie (Flow Cytometry), Immunhistochemie (Gefrierschnitte), Immunhistochemie (IHC), Immunhistochemie (Paraffingewebe), Immunpräzipitation, Western Blot
Konjugation Format Zweckbestimmung Temperatur - Lagerung Hersteller / Marke -
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The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
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