Anti-BRAF V600E (Hu) aus Maus (IHC600) – unkonj.
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Übersicht
Artikelnummer AB-138191 Spezifität Spezies-Reaktivität Immunogen Wirtsspezies Klon Klonalität (Mono-/Polyklonal) Anwendung ELISA (Enzyme Linked Immunosorbent Assay), Immunhistochemie (IHC), Immunhistochemie (Paraffingewebe)
Konjugation Verdünnung vorverdünnt, gebrauchsfertig (erfordert keine weitere Verdünnung)
Format gebrauchsfertig, gereinigter vorverdünnter Antikörper, in Antikörper-Verdünnungspuffer
Zweckbestimmung Temperatur - Lagerung Temperatur - Transport Hersteller / Marke Alias BRAF, BRAF V600E, BRAF1, Proto-oncogene B-Raf, Serine/threonine-protein kinase B-raf, v-Raf murine sarcoma viral oncogene homolog B1
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Serine/Threonine-Protein Kinase B-Raf (BRAF) is a cytoplasmic serine-threonine kinase of the RAF family, which mediates downstream cellular responses to growth signals through the mitogen-activated protein kinase (MAPK) signaling pathway. Oncogenic mutations in the BRAF gene, 80% of which are a single V600E substitution within the kinase domain, constitutively activate the MAPK signaling pathway and result in increased cell proliferation and apoptosis resistance. The V600E mutation is observed in colorectal cancer, non-Hodgkin’s lymphoma, papillary thyroid carcinoma, malignant melanoma, non-small-cell lung carcinoma, and lung adenocarcinoma. BRAF V600E is therefore an important immunohistochemical marker for tumour diagnosis and prognosis.
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