Anti-DNA mismatch repair protein Mlh1 (MLH1) (Hu) aus Maus (IHC409) – unkonj.
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Übersicht
Artikelnummer AB-138250 Spezifität Spezies-Reaktivität Immunogen Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung ELISA (Enzyme Linked Immunosorbent Assay), Immunhistochemie (IHC), Immunhistochemie (Paraffingewebe)
Konjugation Verdünnung Format < 0,1% NaN3, 1% BSA, in Tris Puffer (pH 7,3-7,7), Konzentrat, ProteinA/G-gereinigter Antikörper
Zweckbestimmung Temperatur - Lagerung Temperatur - Transport Hersteller / Marke Uniprot_ID Gene_ID Alias DNA mismatch repair protein Mlh1, MLH1, MutL protein homolog 1
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Weitere Produktinformationen
MutL Homolog 1 (MLH1) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, as the MLH1 gene is frequently mutated in patients with this cancer. Studies have shown MLH1 to be deficient in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MLH1 is optimized when paired in an IHC panel with MSH6, MSH2, and PMS2. Anti-MLH1 is useful in the detection of MLH1 in a number of normal and neoplastic tissues, and for identifying a loss of MLH1 in tumours that are microsatellite-unstable.
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Bilder
Immunhistochemische Färbung formalinfixierter Paraffinschnitte (FFPE) von menschlichem Ösophagus-Gewebe unter Verwendung des monoklonalen Anti-MLH1 Antikörpers (Klon IHC409).
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