Anti-Transcription Factor SOX-10 (SOX10) (Hu) aus Maus (IHC010) – unkonj.
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Übersicht
Artikelnummer AB-138437 Spezifität Spezies-Reaktivität Immunogen Wirtsspezies Isotyp Klon Klonalität (Mono-/Polyklonal) Anwendung ELISA (Enzyme Linked Immunosorbent Assay), Immunhistochemie (IHC), Immunhistochemie (Paraffingewebe)
Konjugation Verdünnung Format < 0,1% NaN3, 1% BSA, in Tris Puffer (pH 7,3-7,7), Konzentrat, ProteinA/G-gereinigter Antikörper
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Weitere Produktinformationen
SRY (Sex Determining Region Y)-Box 10 (SOX10), also known as Transcription Factor SOX10, is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX10 is diffusely expressed in neurofibromas and schwannomas, and mutations in the SOX10 gene are linked to Waardenburg-Shah and Waardenburg-Hirschsprung‘s disease. Anti-SOX10 has been shown to be sensitive for conventional, spindled, and desmoplastic melanoma, and has been used to detect metastatic melanoma and nodal capsular nevus in sentinel lymph nodes.
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Bilder
Immunhistochemische Färbung formalinfixierter Paraffinschnitte (FFPE) von menschlichem Melanom-Gewebe unter Verwendung des monoklonalen Anti-SOX-10 Antikörpers (Klon IHC010).
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