Anti-Transcription Factor SOX-10 (SOX10) (Hu) from Mouse (IHC010) – unconj.
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Overview
SKU AB-138437 Specificity Species Reactivity Immunogen Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections)
Conjugation Dilution Format < 0.1% NaN3, 1% BSA, concentrate, in Tris buffer (pH 7.3-7.7), ProteinA/G purified antibody
Intended Use Temperature - Storage Temperature - Transport Manufacturer / Brand Uniprot_ID Gene_ID Alias - Datasheets and Downloads
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Additional Product Information
SRY (Sex Determining Region Y)-Box 10 (SOX10), also known as Transcription Factor SOX10, is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX10 is diffusely expressed in neurofibromas and schwannomas, and mutations in the SOX10 gene are linked to Waardenburg-Shah and Waardenburg-Hirschsprung‘s disease. Anti-SOX10 has been shown to be sensitive for conventional, spindled, and desmoplastic melanoma, and has been used to detect metastatic melanoma and nodal capsular nevus in sentinel lymph nodes.
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Images
Immunohistochemical staining of formalin-fixed and paraffin-embedded (FFPE) human melanoma tissue section using anti-SOX-10 mouse monoclonal antibody (Clone IHC010).
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