Clone RM192: Specific detection of Histone-H3-K27M
Clone RM192 by RevMAb Biosciences allows the specific detection of the Histone H3 K27M mutant in FFPE-tissue samples. The lysin residue (K) at position 27 of the amino acid chain is replaced by a methionine residue (M) in K27M mutant proteins. The monoclonal rabbit antibody does not cross react with wild-type Histone H3.
Western Blot analysis of cell lysates prepared from 293T transfected with a DNA construct encoding wild type (WT) or K27M mutant proteins of Histone H3.3, using anti-Histone H3 K27M rabbit monoclonal antibody, clone RM192.
Image courtesy of Sebastian Brandner MD, Division of Neuropathology and Dept. of Neurodegenerative Disease, UCL Institute of Neurology, London, UK
Clone 13/45/31 detects N- /C-terminal and internal Histidin-tagged proteins in cells and complex cellular lysates with highest affinity (Biacore 3×10-10M). More than 100 citations demonstrate the outstanding affinity and sensitivity for His-labeled proteins.
Prostate Specific Antigen IHC – Performance redefined!
Now available: Best validated anti-PSA antibody worldwide. Clone HAM18 has been tested on 21.000 tissue sections and is optimized for IHC on formalin-fixed paraffin-embedded (FFPE) prostate tissue specimen to be used in brightfield immunohistochemistry but also for fluorescent multiplex immunohistochemistry (mIHC).
Antibody clone HAM18 is absolutely PSA-specific. It stains only prostate epithelium and derived cells. Numerous publications on PSA positive staining of other, non-PSA expressing tumor tissues suggest cross-reactivity of commonly available PSA antibodies. The exceptionally high sensitivity of HAM18 also allows the detection of subtotal to total loss of PSA expression in poorly differentiated tumors of high grades.