Our offer for your IHC on glioma tissue: Get a 20% discount on your anti-IDH1 R132H antibody DIA-H09 when ordering together with ATRX or H3.K27M from dianova*

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IDH1 R132H

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ATRX

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H3 K27M

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The WHO-classification for CNS Tumors 2016 recommends the analysis of new molecular markers on formalin-fixed tissues together with classical histomorphology. The focus here is on immunohistochemical determination of the IDH1, ATRX and H3-K27M mutation status. Successive integration of IHC procedures reduces the number of molecular tests required for unequivocal diagnosis (Reus et al., 2015).

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* Valid until July 1^st, 2020. Applies to the combination of ATRX or H3 K27M with one IDH1 R132H antibody DIA-H09 each. When placing placing your order pleace indicate your offer number: 38249

We develop antibodies for the tissue-based detection of immune checkpoint markers

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ONCOdianova concentrates on development of new antibody clones for the tissue-based detection of cancer immunology biomarkers. ONCOdianova’s vision is to provide the best antibodies for immunohistochemical analysis of biomarker expression profiles to better understand the complex interaction of immune cells and the tumor cells in patient tissue. ONCOdianova believes that multiplexed IHC-assessment of immune checkpoint targets in tumor tissues is indispensable for cancer research.

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Learn more about TIGIT & cancer immunology checkpoint blockade

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Anti-(His)₆ Epitop-Tag Antibody (Clone 13/45/31)

Clone 13/45/31 detects N- /C-terminal and internal Histidin-tagged proteins in cells and complex cellular lysates with highest affinity (Biacore 3×10^-10M). More than 100 citations demonstrate the outstanding affinity and sensitivity for His-labeled proteins.

Find the right secondary antibody in six easy steps

dianova – Your #1 source for secondary antibodies in Germany. Download our secondary antibody selection guide or request a print copy.

Clone RM192: Specific detection of Histone-H3-K27M

Clone RM192 by RevMAb Biosciences allows the specific detection of the Histone H3 K27M mutant in FFPE-tissue samples. The lysin residue (K) at position 27 of the amino acid chain is replaced by a methionine residue (M) in K27M mutant proteins. The monoclonal rabbit antibody does not cross react with wild-type Histone H3.

Image courtesy of Sebastian Brandner MD, Division of Neuropathology and Dept. of Neurodegenerative Disease, UCL Institute of Neurology, London, UK

CD73-adenosine IHC – Performance redefined!

Now available: Clone KK3 has been developed and validated specifically for the immunohistochemical (IHC) detection of CD73-adenosine checkpoint in routine FFPE human tissue sections.

Prostate Specific Antigen IHC – Performance redefined!

Now available: Best validated anti-PSA antibody worldwide. Clone HAM18 has been tested on 21.000 tissue sections and is optimized for IHC on formalin-fixed paraffin-embedded (FFPE) prostate tissue specimen to be used in brightfield immunohistochemistry but also for fluorescent multiplex immunohistochemistry (mIHC).

Antibody clone HAM18 is absolutely PSA-specific. It stains only prostate epithelium and derived cells. Numerous publications on PSA positive staining of other, non-PSA expressing tumor tissues suggest cross-reactivity of commonly available PSA antibodies. The exceptionally high sensitivity of HAM18 also allows the detection of subtotal to total loss of PSA expression in poorly differentiated tumors of high grades.

Optimize VHH antibody (Nanobody) development with Jackson secondary antibodies for VHH discovery.

Learn more about detection of camelid IgG-subclasses, single domain antibodies (VHH-antibodies) or alpaca-antibodies in general.