Obesity and Diabetes: Metabolic Marker Antibodies

Obesity and diabetes are rapidly increasing around the world. Whereas obesity has already reached epidemic proportions globally, a diabetes epidemic is underway. Obesity is associated with a higher incidence of a number of diseases, including diabetes, cardiovascular disease, and cancer. At least 2.8 million people are dying each year as a result of being overweight or obese.

Thus the study of factors involved in the regulation of appetite, food intake, glucose homeostasis, insulin secretion, and energy balance have highest priority in the area of nutrition, obesity and metabolism. Understanding the pathogenesis of obesity and type 2 diabetes is essential for the development of new drugs and therapeutic options.

The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect appetite, digestion, and energy expenditure. With the growing number of people suffering from obesity and diabetes, there is an increased focus on research within gut hormones.

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Anorexigenic and orexigenic hormones

The main mechanisms of action of gastrointestinal hormones on appetite regulation.

HormoneAnorexigenic / Appetite suppression
GLP-1Glucose-dependent insulin release (incretin effect), delays gastric emptying, regulates satiety
GLP-2Regulates gastric motility, promotes nutrient absorption, increases the barrier function of the gut epithelium
OxyntomodulinGlucose-dependent insulin release (incretin-like properties), delays gastric emptying, regulates satiety
PYYDelays gastric emptying, regulates satiety
CKKDelays gastric emptying, stimulates gallbladder contraction, stimulates pancreatic enzyme secretion
GIPGlucose-dependent insulin release (incretin effect)
PPDelays gastric emptying, regulates satiety
GlucagonGluconeogenesis, glycogenolysis
AmylinDelays gastric emptying, inhibits gastric secretion, decreases blood glucose
LeptinRegulates energy metabolism
HormoneOrexigenic / Appetite stimulation
GhrelinIncreases gastric motility (Hunger hormone), stimulates growth hormone release

Through dedicated research, BioPorto Diagnostics offers the world’s leading commercial portfolio of antibodies for metabolic markers.

  • High specificity
  • Proven quality and consistency for assay development
  • Matched antibody pairs available

GLP-1 and Exendin-4 Antibodies

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GIP and Oxyntomodulin Antibodies

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All Metabolic Marker Antibodies