Anti-Histone H3 (K27M) (all) from Rabbit (RM192) – unconj.
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Overview
SKU 31-1175-00-S Specificity Species Reactivity Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application ELISA, Immunocytochemistry, Immunohistochemistry (IHC), Western Blot
Conjugation Format Application Note No cross reactivity with wild type Histone H3, Reacts to the Histone H3 K27M mutant
Product line / Topic Intended Use Temperature - Storage Manufacturer / Brand - Datasheets and Downloads
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Additional Product Information
This antibody reacts to the Histone H3 K27M mutant. No cross reactivity with wild type Histone H3.
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Images
Immunostaining of brain tumor tissue sections using both EDTA and Citrate pretreatment methods. Clinically validated to be Positive for the H3.3 K27M Mutation by Sanger sequencing. Image courtesy of Sebastian Brandner MD, Division of Neuropathology and De Immunostaining of brain tumor tissue sections using both EDTA and Citrate pretreatment methods. Clinically validated to be Negative for the H3.3 K27M Mutation by Sanger sequencing. Image courtesy of Sebastian Brandner MD, Division of Neuropathology and De Western Blot analysis of cell lysates prepared from 293T transfected with a DNA construct encoding wild type (WT) or K27M mutant proteins of Histone H3.3, using 0.01 ug/mL of anti-Histone H3 K27M rabbit monoclonal antibody clone RM192. Immunohistochemical staining of formalin fixed and paraffin embedded 293T cells transfected with a DNA construct encoding Histone H3 K27M mutant, stained with 0.01 ug/mL of anti-Histone H3 K27M rabbit monoclonal antibody clone RM192.
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