Anti-Multidrug resistance protein 3 (ABCB4) (Hu) from Mouse (IHC621) – unconj.
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Overview
SKU AB-138357 Specificity Species Reactivity Immunogen Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections)
Conjugation Dilution Format < 0.1% NaN3, 1% BSA, concentrate, in Tris buffer (pH 7.3-7.7), ProteinA/G purified antibody
Intended Use Temperature - Storage Temperature - Transport Manufacturer / Brand Uniprot_ID Gene_ID Alias ABCB4, ATP Binding Cassette Subfamily B Member 4, ATP-binding cassette sub-family B member 4, MDR3, Multidrug resistance protein 3, Phosphatidylcholine translocator ABCB4
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Additional Product Information
Multidrug Resistance 3 (MDR3), also known as ATP Binding Cassette Subfamily B Member 4 (ABCB4), is a membrane-associated protein belonging to the superfamily of ATP-binding cassette transporters. MDR3 is an energy-dependent phospholipid efflux translocator that mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte, and also acts as a positive regulator of biliary lipid secretion. Defects in MDR3 are associated with progressive familial intrahepatic cholestasis type 3 and gallbladder disease type 1. Co-overexpression of MDR3 and MRP1 has been documented as correlating with blastemal subtype and high-risk prognosis of Wilms‘ tumour patients.
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Images
Immunohistochemical staining of formalin-fixed and paraffin-embedded (FFPE) human liver tissue section using anti-MDR3 mouse monoclonal antibody (Clone IHC621).
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