Anti-Insulin (Hu,Bo,Sw,Rb,Rt) from Mouse (E2-E3+2D11-H5,INS04+INS05) – unconj.

Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through disulfide bonds. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin producing the insulin molecule and the C-peptide. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta cell and insulinoma marker.