Anti-NGF Receptor (Ca,Hu,Mo) from Mouse (NGFR5) – unconj.
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Overview
SKU RA0247-C.5 Specificity Species Reactivity Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application Immunohistochemistry (frozen sections), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections), Immunoprecipitation
Conjugation Format Intended Use Temperature - Storage Manufacturer / Brand -
Additional Product Information
Recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75, NGFR) or Neurotrophin Receptor (p75, NTR). Its epitope resides within aa 1-160 of the extracellular domain of NGFR/NTR. NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of a variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and the low affinity p75.
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