Anti-CD45RA (Hu,Dg,Ca,Ms,Rb,Sw,Rt,Ck) from Mouse (158-4D3 (WS V, C. CD45.38)) – unconj.

This antibody recognizes a protein of 205kDa-220kDa, identified as CD45RA. CD45RA is an isoform of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B, and C, respectively. The differential splicing of the exons generates at least five isoforms: ABC, AB, BC, B, and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This antibody is useful in studying the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B-cell lymphomas (CD45RA +ve).