Anti-DOG1 (Hu) from Mouse (DG1/447 + DOG-1.1) – unconj.

This monoclonal antibody recognizes Human DOG1. It is a sensitive and specific immunohistochemical marker for GIST, comparable with KIT, with the additional benefit of detecting KIT-negative GISTs. It is also a sensitive marker for unusual GIST subgroups lacking KIT or PDGFRA mutations. Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST is), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST is, including all c-kit negative GIST is. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST is is nearly identical: 94.4% vs. 94.7%.