Anti-CA19-9 (Hu) from Mouse (121SLE) – unconj.
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Overview
SKU RA0397-C.5 Specificity Species Reactivity Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application Flow Cytometry, Immunohistochemistry (frozen sections), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections)
Conjugation Format Intended Use Temperature - Storage Manufacturer / Brand Alias CA 19-9, CA19-9, Carbohydrate antigen19-9, Ovarian tumor antigen, Pancreatic tumor antigen, Sialyl-Lewis a
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Additional Product Information
CA19-9, a carbohydrate epitope expressed on a high MW (>400kDa) mucin glycoprotein, is a sialyl Lewis a structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewis a and/or Lewis b blood group antigens. In normal tissues, sialyl Lewis a antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands. Its expression is greatly enhanced in serum as well as in the majority of tumor cells in gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas. Preoperative elevated CA19-9 levels in patients with stage I pancreatic carcinoma decrease to normal values following surgery. When used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings. This antibody is superb for staining of formalin-fixed, paraffin-embedded tissues.
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