Anti-MUC1 (Mucin-1) / EMA (Hu) from Mouse (IHC623) – unconj.
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Overview
SKU AB-138344 Specificity Species Reactivity Immunogen Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections)
Conjugation Dilution Format < 0.1% NaN3, 1% BSA, concentrate, in Tris buffer (pH 7.3-7.7), ProteinA/G purified antibody
Intended Use Temperature - Storage Temperature - Transport Manufacturer / Brand Uniprot_ID Gene_ID Alias CA153, Cancer antigen 15-3, Carcinoma-associated mucin, CD227, EMA, Episialin, H23AG, KL-6, MUC1, Mucin 1, Mucin-1, Peanut-reactive urinary mucin, PEM, Polymorphic epithelial mucin, PUM
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Additional Product Information
Mucin 1 (MUC1) is a membrane-bound glycoprotein involved in a number of protective and cell-signaling functions, including cell-cell adhesion, proliferation, motility, invasion, and survival. Overexpression of MUC1 is clinically indicated in breast carcinomas, papillary thyroid carcinomas, and thymic carcinomas, and reports have named MUC1 as a useful marker for differentiating thymic carcinoma from type B3 thymoma. The expression of MUC1 is correlated with the grade of malignancy in thymic epithelial tumours, and loss of MUC1 expression has been associated with reactive gastropathy. MUC1 is not expressed in normal human epidermis, but it has been detected in the epidermis of psoriatic plaques of biopsies from patients diagnosed with psoriasis vulgaris.
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Images
Immunohistochemical staining of formalin-fixed and paraffin-embedded (FFPE) human breast cancer tissue section using anti-MUC1 mouse monoclonal antibody (Clone IHC623).
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