Anti-CD45R (B220) (Hu) from Mouse (IHC536) – unconj.
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Overview
SKU AB-179487 Specificity Species Reactivity Immunogen Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections)
Conjugation Dilution Format < 0.1% NaN3, 1% BSA, concentrate, in Tris buffer (pH 7.3-7.7), ProteinA/G purified antibody
Intended Use Temperature - Storage Temperature - Transport Manufacturer / Brand Uniprot_ID Gene_ID Alias B220, CD45, CD45RA, Cluster of Differentiation 45, L-CA, LCA, Leukocyte Common Antigen, Ly-5, LY5, PTPRC, Receptor-type tyrosine-protein phosphatase C, T200
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Additional Product Information
CD45R, also known as MB1, is an isoform of CD45 that is a member of the protein tyrosine phosphatase (PTPase) family. CD45R is expressed specifically on the surface of hematopoietic cells, and has demonstrated function as a regulator of the antigen and cytokine receptor signalling of B and T cells. Given that the antigen is located in the membrane of all B cells, with the exception of plasma cells and some mature T cells, Anti-CD45R exhibits specific reactivity with most B lymphocytes. The use of Anti-CD45R is primarily useful in distinguishing B cell lymphomas from T cell lymphomas, with specific reactivity to follicle center cells, mantle cells, some medullary thymocytes, and 80% of B cell lymphomas.
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Images
Immunohistochemical staining of formalin-fixed and paraffin-embedded (FFPE) human tonsil tissue section using anti-CD45R (B220) mouse monoclonal antibody (Clone IHC536).
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