Anti-Cyclin D1 (Hu,Rb,Rt,Ms,Sw,Ca,Ck,Mo,Ro) from Mouse (DCS-6) – unconj.
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Overview
SKU RA0426-C.5 Specificity Species Reactivity Cat, Chicken, Human, Monkey, Mouse, Rabbit, Rat, Rodents, Swine
Host Species Isotype Clone Clonality (Mono-/Polyclonal) Application Flow Cytometry, Immunohistochemistry (frozen sections), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections), Immunoprecipitation
Conjugation Format Intended Use Temperature - Storage Manufacturer / Brand -
Additional Product Information
Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11, 14)(q13, q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
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